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igv (integrated genome viewer) software  (Broad Institute Inc)

 
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    Structured Review

    Broad Institute Inc igv (integrated genome viewer) software
    ( A – E ) The transcriptome (6 h p.i.) of IAV infected cells were NGS-sequenced and the sorted reads were aligned to the human genome (GRCh37/hg19). The aligned reads were viewed using the <t>IGV</t> (integrated genome viewer) software from the Broad Institute. Shown are the alignments of the reads downstream of the polyadenylation site (pA=poly adenylation site, marked by an arrow) of the host genes A IFN1B (interferon beta 1), B NFKBIZ (NFKB Inhibitor Zeta) and C IFIT3 (Interferon Induced Protein with Tetratricopeptide Repeats 3), D MX1 (Interferon-Induced GTP-Binding Protein Mx1), E ISG20 (interferon stimulated gene 20),. Shown is a region of roughly 20 kb downstream of the poly adenylation site of each gene. L1: reads from IAV-NS1-Cyclin L1 (aa318-525) infected cells; life: reads from IAV-lifeAct NS1 infected cells; wt: reads from IAV wt infected cells. F Overall the percentage of reads up to 10 kb downstream of poly A sites is not significantly different between wt-IAV, IAV-NS1-CyclinL1, and IAV-lifeActNS1 infected cells suggesting that only a subset of transcriptional terminations is deregulated.
    Igv (Integrated Genome Viewer) Software, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/igv (integrated genome viewer) software/product/Broad Institute Inc
    Average 90 stars, based on 1 article reviews
    igv (integrated genome viewer) software - by Bioz Stars, 2026-06
    90/100 stars

    Images

    1) Product Images from "Influenza A virus NS1 suppresses nuclear speckles promoted gene expression by inhibition of transcription"

    Article Title: Influenza A virus NS1 suppresses nuclear speckles promoted gene expression by inhibition of transcription

    Journal: npj Viruses

    doi: 10.1038/s44298-025-00124-x

    ( A – E ) The transcriptome (6 h p.i.) of IAV infected cells were NGS-sequenced and the sorted reads were aligned to the human genome (GRCh37/hg19). The aligned reads were viewed using the IGV (integrated genome viewer) software from the Broad Institute. Shown are the alignments of the reads downstream of the polyadenylation site (pA=poly adenylation site, marked by an arrow) of the host genes A IFN1B (interferon beta 1), B NFKBIZ (NFKB Inhibitor Zeta) and C IFIT3 (Interferon Induced Protein with Tetratricopeptide Repeats 3), D MX1 (Interferon-Induced GTP-Binding Protein Mx1), E ISG20 (interferon stimulated gene 20),. Shown is a region of roughly 20 kb downstream of the poly adenylation site of each gene. L1: reads from IAV-NS1-Cyclin L1 (aa318-525) infected cells; life: reads from IAV-lifeAct NS1 infected cells; wt: reads from IAV wt infected cells. F Overall the percentage of reads up to 10 kb downstream of poly A sites is not significantly different between wt-IAV, IAV-NS1-CyclinL1, and IAV-lifeActNS1 infected cells suggesting that only a subset of transcriptional terminations is deregulated.
    Figure Legend Snippet: ( A – E ) The transcriptome (6 h p.i.) of IAV infected cells were NGS-sequenced and the sorted reads were aligned to the human genome (GRCh37/hg19). The aligned reads were viewed using the IGV (integrated genome viewer) software from the Broad Institute. Shown are the alignments of the reads downstream of the polyadenylation site (pA=poly adenylation site, marked by an arrow) of the host genes A IFN1B (interferon beta 1), B NFKBIZ (NFKB Inhibitor Zeta) and C IFIT3 (Interferon Induced Protein with Tetratricopeptide Repeats 3), D MX1 (Interferon-Induced GTP-Binding Protein Mx1), E ISG20 (interferon stimulated gene 20),. Shown is a region of roughly 20 kb downstream of the poly adenylation site of each gene. L1: reads from IAV-NS1-Cyclin L1 (aa318-525) infected cells; life: reads from IAV-lifeAct NS1 infected cells; wt: reads from IAV wt infected cells. F Overall the percentage of reads up to 10 kb downstream of poly A sites is not significantly different between wt-IAV, IAV-NS1-CyclinL1, and IAV-lifeActNS1 infected cells suggesting that only a subset of transcriptional terminations is deregulated.

    Techniques Used: Infection, Software, Binding Assay



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    ( A – E ) The transcriptome (6 h p.i.) of IAV infected cells were NGS-sequenced and the sorted reads were aligned to the human genome (GRCh37/hg19). The aligned reads were viewed using the <t>IGV</t> (integrated genome viewer) software from the Broad Institute. Shown are the alignments of the reads downstream of the polyadenylation site (pA=poly adenylation site, marked by an arrow) of the host genes A IFN1B (interferon beta 1), B NFKBIZ (NFKB Inhibitor Zeta) and C IFIT3 (Interferon Induced Protein with Tetratricopeptide Repeats 3), D MX1 (Interferon-Induced GTP-Binding Protein Mx1), E ISG20 (interferon stimulated gene 20),. Shown is a region of roughly 20 kb downstream of the poly adenylation site of each gene. L1: reads from IAV-NS1-Cyclin L1 (aa318-525) infected cells; life: reads from IAV-lifeAct NS1 infected cells; wt: reads from IAV wt infected cells. F Overall the percentage of reads up to 10 kb downstream of poly A sites is not significantly different between wt-IAV, IAV-NS1-CyclinL1, and IAV-lifeActNS1 infected cells suggesting that only a subset of transcriptional terminations is deregulated.
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    ( A – E ) The transcriptome (6 h p.i.) of IAV infected cells were NGS-sequenced and the sorted reads were aligned to the human genome (GRCh37/hg19). The aligned reads were viewed using the <t>IGV</t> (integrated genome viewer) software from the Broad Institute. Shown are the alignments of the reads downstream of the polyadenylation site (pA=poly adenylation site, marked by an arrow) of the host genes A IFN1B (interferon beta 1), B NFKBIZ (NFKB Inhibitor Zeta) and C IFIT3 (Interferon Induced Protein with Tetratricopeptide Repeats 3), D MX1 (Interferon-Induced GTP-Binding Protein Mx1), E ISG20 (interferon stimulated gene 20),. Shown is a region of roughly 20 kb downstream of the poly adenylation site of each gene. L1: reads from IAV-NS1-Cyclin L1 (aa318-525) infected cells; life: reads from IAV-lifeAct NS1 infected cells; wt: reads from IAV wt infected cells. F Overall the percentage of reads up to 10 kb downstream of poly A sites is not significantly different between wt-IAV, IAV-NS1-CyclinL1, and IAV-lifeActNS1 infected cells suggesting that only a subset of transcriptional terminations is deregulated.
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    90
    Broad Institute Inc igv software (integrative genome viewer, 2013)
    ( A – E ) The transcriptome (6 h p.i.) of IAV infected cells were NGS-sequenced and the sorted reads were aligned to the human genome (GRCh37/hg19). The aligned reads were viewed using the <t>IGV</t> (integrated genome viewer) software from the Broad Institute. Shown are the alignments of the reads downstream of the polyadenylation site (pA=poly adenylation site, marked by an arrow) of the host genes A IFN1B (interferon beta 1), B NFKBIZ (NFKB Inhibitor Zeta) and C IFIT3 (Interferon Induced Protein with Tetratricopeptide Repeats 3), D MX1 (Interferon-Induced GTP-Binding Protein Mx1), E ISG20 (interferon stimulated gene 20),. Shown is a region of roughly 20 kb downstream of the poly adenylation site of each gene. L1: reads from IAV-NS1-Cyclin L1 (aa318-525) infected cells; life: reads from IAV-lifeAct NS1 infected cells; wt: reads from IAV wt infected cells. F Overall the percentage of reads up to 10 kb downstream of poly A sites is not significantly different between wt-IAV, IAV-NS1-CyclinL1, and IAV-lifeActNS1 infected cells suggesting that only a subset of transcriptional terminations is deregulated.
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    ( A – E ) The transcriptome (6 h p.i.) of IAV infected cells were NGS-sequenced and the sorted reads were aligned to the human genome (GRCh37/hg19). The aligned reads were viewed using the IGV (integrated genome viewer) software from the Broad Institute. Shown are the alignments of the reads downstream of the polyadenylation site (pA=poly adenylation site, marked by an arrow) of the host genes A IFN1B (interferon beta 1), B NFKBIZ (NFKB Inhibitor Zeta) and C IFIT3 (Interferon Induced Protein with Tetratricopeptide Repeats 3), D MX1 (Interferon-Induced GTP-Binding Protein Mx1), E ISG20 (interferon stimulated gene 20),. Shown is a region of roughly 20 kb downstream of the poly adenylation site of each gene. L1: reads from IAV-NS1-Cyclin L1 (aa318-525) infected cells; life: reads from IAV-lifeAct NS1 infected cells; wt: reads from IAV wt infected cells. F Overall the percentage of reads up to 10 kb downstream of poly A sites is not significantly different between wt-IAV, IAV-NS1-CyclinL1, and IAV-lifeActNS1 infected cells suggesting that only a subset of transcriptional terminations is deregulated.

    Journal: npj Viruses

    Article Title: Influenza A virus NS1 suppresses nuclear speckles promoted gene expression by inhibition of transcription

    doi: 10.1038/s44298-025-00124-x

    Figure Lengend Snippet: ( A – E ) The transcriptome (6 h p.i.) of IAV infected cells were NGS-sequenced and the sorted reads were aligned to the human genome (GRCh37/hg19). The aligned reads were viewed using the IGV (integrated genome viewer) software from the Broad Institute. Shown are the alignments of the reads downstream of the polyadenylation site (pA=poly adenylation site, marked by an arrow) of the host genes A IFN1B (interferon beta 1), B NFKBIZ (NFKB Inhibitor Zeta) and C IFIT3 (Interferon Induced Protein with Tetratricopeptide Repeats 3), D MX1 (Interferon-Induced GTP-Binding Protein Mx1), E ISG20 (interferon stimulated gene 20),. Shown is a region of roughly 20 kb downstream of the poly adenylation site of each gene. L1: reads from IAV-NS1-Cyclin L1 (aa318-525) infected cells; life: reads from IAV-lifeAct NS1 infected cells; wt: reads from IAV wt infected cells. F Overall the percentage of reads up to 10 kb downstream of poly A sites is not significantly different between wt-IAV, IAV-NS1-CyclinL1, and IAV-lifeActNS1 infected cells suggesting that only a subset of transcriptional terminations is deregulated.

    Article Snippet: The aligned reads were viewed using the IGV (integrated genome viewer) software from the Broad Institute.

    Techniques: Infection, Software, Binding Assay